Histopathological study of kidneys of mice with schistosoma mansoni induced glomerular changes before and after praziquantel treatment

Mice were infected by Schistosoma mansoni, the glomerular lesions, in the form of endocapillary cellular proliferation, which occured, hand in hand with the development of proteinuria, were described histopathologically. Treatment with Praziquantel [PZ] did not result in histological worsening or decrease of the lesions, but juxtaglomerular apparatus [JGA] hyperplasia was noted

Effect of diazinon on liver of mice experimentally infected with schistosoma mansoni

Diazinon, a broad spectrum non systemic insecticide, of wide range of use in Egypt nowadays, has been used in the present study, in doses comparable to those used in Agriculture and Veterinary Medicine. Parameters of assessment of liver functions were based on biochemical and pathological data. The biochemical changes in blood, reflected the histologic patterns of toxic hepatic injury. A definite logarithmic rise in the serum enzyme level of transaminases [SGOT and SGPT], and also alkaline phosphatase [ALP] was elicited in Diazinon exposed mice whether infected or not. However, Diazinon induced no significant changes in the serum levels regarding total bilirubin, total protein, albumin, globulin and albumin globulin [A/G] ratio. Histopathological examination of the liver tissue of the Diazinon exposed groups of mice, demonstrated necrosis and inflammatory cellular infiltration. However, necrosis in the S. mansoni infected exposed group, was more pronounced; extending from focal to extensive necrosis in accordance to the concentration of the formulation applied. Necrosis was more advanced on using higher concentrations of Diazinon running in parallel to the increase in the serum enzyme levels

assessment of hepatic functional capacities and haemoglobin values in amaebiasis

Fourty adult males with amaebiasis and a match control group of the same age and sex were subjected to complete blood examination. The results showed that the mean values for total serum protein, total serum bilirubin, A. L. P, and Hb% were within the acceptable limits i. e. statistically insignificant, whilst A. S. T. and A.L.T, were not within the acceptable limits, i. e. statistically insignificant, whilst A. S. T. and A. L. T. were not within the acceptable limits, i. e. statistically significant. The percentages of normals as regards the frequency distribution test were as follows Total serum protein [80%], total serum bilirubin [82. 5%], A. L. P. [94. 59%], A. S. T. [67. 5%], A. L. T. [75%] and Hb. [86. 21%]. The regression analysis test, confirmed by the correlation test, were performed to indicate the relationship between the intensity of infection [indicated by the population of E. histolytica in stool analysis] and the serum levels of the tests to follow. Accordingly the serum levels of A. L. P., A. S. T. and A. L. T. showed a relatively slight increase, while the total serum protein level and Hb% showed a slight decrease. The serum bilirubin indicated no change whatsoever